Micky van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender became the initial defender to score two goals in a Premier League game for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven heads into the net twice in opening period
Everton's defender has goal disallowed after VAR review
Senegalese midfielder scores third in 89th minute
This loss is the Merseyside club's first at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their winning streak on the road in the top division and handed the Toffees their initial loss at their new home.
Everton were undefeated in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman struck on two occasions from corners in the opening 45 minutes to place their strong form at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - nodded in a final goal to seal the victory.
Jake O'Brien believed he had levelled the tally five minutes after Van de Ven's opener, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a number of opportunities, while the Italian goalkeeper made a succession of excellent stops to guarantee the London club went five away games unbeaten in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to check the goal on the screen and the referee decided that Jack Grealish and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's side up to third in the division, five points off local foes and leaders the Gunners.
Everton remain 14th and sit half a dozen points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at both ends of the field
Following a drab weekday display in the Champions League against Monaco, where they mustered a only attempts on goal, the manager chose the French striker up front instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after an hour on the field, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven converted into an attacking force to be feared.
Tottenham's first goal came from a well-worked corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - added his next goal in first-half stoppage time as he rose above Jordan Pickford to nod in.
The Dutchman was just as outstanding in defensive duties, partnering well with Kevin Danso as the pair dealt excellently with the 34 crosses sent their way by the opposition.
Everton analysis: Everton missing striker's instinct
The club's new home had been a fortress, but it appears the novelty may have worn off somewhat and fans headed to the exits after the midfielder's third for Spurs.
The break in Everton's unbeaten home run will not be a massive worry for the manager, but their striker situation will be.
The forward and Thierno Barry - the Toffees' pair of established centre-forwards - had scored just one league goal combined before the weekend's match.
And they were unable to contribute to that poor record on a wet and gloomy evening on in Liverpool.
Beto's form was epitomized when he chose to overhead kick a golden opportunity from close range, even with having space and opportunity to readjust for a more conventional attempt that would have challenged Vicario.
The substitute, as well, failed to make an impact after replacing the starter in the 65th minute.
It wasn't for a shortage of opportunity. The majority of the home side's offensive moves came through Grealish and Ndiaye, who relentlessly whipped threatening balls into the Spurs penalty area.
What next for both teams?
Everton: The team travel to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.